Carlo Brugnara Selected Research

Clotrimazole (Lotrimin)

1/2018	Sickle cell dehydration: Pathophysiology and therapeutic applications.
8/2005	Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis.
12/2003	Sickle cell disease: from membrane pathophysiology to novel therapies for prevention of erythrocyte dehydration.
3/2003	ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice.

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Carlo Brugnara Research Topics

Disease

25	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022 - 05/2002
17	Anemia 01/2021 - 10/2003
14	Dehydration (Water Stress) 03/2020 - 01/2003
10	Iron Deficiencies 01/2021 - 10/2003
8	Hypoxia (Hypoxemia) 01/2022 - 09/2006
6	Thalassemia 01/2021 - 11/2004
5	Inflammation (Inflammations) 01/2019 - 01/2003
4	Hemolytic Anemia 05/2021 - 08/2005
3	Hemolysis 01/2021 - 08/2005
3	Iron Overload 01/2021 - 03/2018
3	Hemorrhage 01/2020 - 10/2008
2	Hereditary Spherocytosis 10/2021 - 08/2005
2	Inborn Genetic Diseases (Disease, Hereditary) 05/2021 - 01/2019
2	beta-Thalassemia (Cooley's Anemia) 01/2020 - 11/2004
2	hereditary Xerocytosis 01/2019 - 01/2017
2	Malaria 01/2018 - 05/2015
2	Pain (Aches) 09/2015 - 03/2003
2	Hemoglobin SC Disease (Disease, Hemoglobin SC) 03/2011 - 12/2003
1	Bone Diseases (Bone Disease) 05/2021
1	Priapism 01/2021
1	Necrosis 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Leg Ulcer 01/2021
1	X-Linked Syndrome Enteropathy Polyendocrinopathy Immune Dysregulation 01/2021
1	Chronic Renal Insufficiency 01/2018
1	Critical Illness (Critically Ill) 01/2015
1	Hypophosphatemia 01/2015
1	Sickle Cell Trait 10/2014
1	Acute Erythroblastic Leukemia (Erythroleukemia) 01/2013
1	Heart Arrest (Cardiac Arrest) 06/2012
1	Jaundice (Icterus) 10/2010
1	Neoplasms (Cancer) 07/2008
1	Pulmonary Arterial Hypertension 06/2008

Drug/Important Bio-Agent (IBA)

13	Hemoglobins (Hemoglobin)IBA 05/2021 - 03/2003
13	IronIBA 01/2021 - 10/2003
9	CationsIBA 01/2022 - 10/2006
5	senicapocIBA 01/2021 - 03/2003
4	Erythropoietin FDA Link 01/2021 - 10/2003
4	K Cl- CotransportersIBA 03/2020 - 06/2007
4	Clotrimazole (Lotrimin)FDA LinkGeneric 01/2018 - 03/2003
3	Fetal Hemoglobin (Hemoglobin F)IBA 01/2019 - 01/2003
3	Oxygen (Dioxygen)IBA 11/2018 - 09/2006
3	Ferritins (Ferritin)IBA 03/2018 - 10/2003
3	Proteins (Proteins, Gene)FDA Link 01/2018 - 11/2006
3	Indicators and Reagents (Reagents)IBA 03/2015 - 07/2004
3	MagnesiumIBA 03/2011 - 01/2005
3	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2010 - 04/2003
3	Transferrin (beta 2 Transferrin)IBA 08/2005 - 10/2003
2	Adenosine Triphosphate (ATP)IBA 01/2022 - 01/2021
2	Grammostola spatulata MTx4 proteinIBA 01/2022 - 01/2010
2	Fatty Acids (Saturated Fatty Acids)IBA 05/2021 - 07/2015
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2005
2	GlobinsIBA 01/2020 - 01/2019
2	HepcidinsIBA 11/2019 - 10/2003
2	Sickle HemoglobinIBA 01/2017 - 01/2003
2	AntioxidantsIBA 07/2015 - 11/2004
2	Protein Isoforms (Isoforms)IBA 11/2006 - 08/2005
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2006 - 03/2003
2	PotassiumIBA 08/2005 - 01/2003
2	Oxidants (Oxidizing Agents)IBA 11/2004 - 01/2003
2	PolymersIBA 01/2003 - 05/2002
1	Apyrase (ATP Diphosphatase)IBA 01/2022
1	AcidsIBA 01/2022
1	Probenecid (Benemid)FDA LinkGeneric 01/2022
1	Suramin (Suramin Sodium)IBA 01/2022
1	Pyruvate KinaseIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Glutamine (L-Glutamine)FDA Link 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021
1	mitapivatIBA 01/2021
1	von Willebrand FactorIBA 01/2020
1	AntigensIBA 01/2020
1	(4- (3- fluoro- 5- trifluoromethylpyridin- 2- yl)piperazin- 1- yl)(5- methanesulfonyl- 2- (2,2,2- trifluoro- 1- methylethoxy)phenyl)methanoneIBA 11/2019
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 11/2019
1	Heme (Haem)IBA 11/2019
1	LipidsIBA 01/2019
1	2- hydroxylamino- 5- ethyl- 5- propylbarbituric acid (HB 2)IBA 03/2018
1	Blood Group Antigens (Blood Groups)IBA 01/2018
1	Ion Channels (Ion Channel)IBA 01/2018
1	Sirolimus (Rapamycin)FDA Link 09/2015
1	Therapeutic UsesIBA 07/2015
1	2,3-Diphosphoglycerate (2,3 Bisphosphoglycerate)IBA 01/2015
1	Phosphates (Orthophosphate)IBA 01/2015
1	ResveratrolIBA 02/2014
1	N- 1- (hydroxy(3- oxo- 2- phenyl- 1- cyclopropen- 1- yl)methyl)- 2- methylpropyl- 2- benzenesulfonylamino- 4- methylpentanamideIBA 02/2013
1	Messenger RNA (mRNA)IBA 01/2013
1	CalciumIBA 11/2012
1	Carbon MonoxideIBA 01/2010
1	hemoglobin ASIBA 01/2009
1	HematinicsIBA 07/2008
1	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 06/2008

Therapy/Procedure

12	Therapeutics 01/2021 - 10/2003
2	Tonsillectomy 01/2020 - 10/2008
1	Cholecystectomy 01/2021
1	Adenoidectomy 01/2020
1	Cautery 01/2020
1	Oral Administration 01/2019
1	Renal Dialysis (Hemodialysis) 01/2018
1	Splenectomy 10/2015
1	Continuous Renal Replacement Therapy 01/2015